T&L Biotechnology

Product Name

Generic Name

OK432

Product Information

Activity

NK cells activated with this product have a cytotoxic index (T-C) of at least 15%

Formulation

lyophilized

Stability & Storage

Samples are stable for up to 24 months from date of receipt at 4 ℃.

Recommend to aliquot OK432 into smaller quantities for optimal storage. Avoid repeated freeze-thaw cycles.

Background

OK432 is a freeze-dried devitalized bacterium. OK432-activated neutrophils could kill IFN-γor TNF-α treated cancers cell. OK432 could induce neutrophil-killing effect on autologous tumor cells through CD11b/CD18 and ICAM-1 binding. OK432-induced monocytes are able to kill autologous tumor cells. After stimulation by OK432, lymphocytes shows fine LAK Cell activity and can even fight against anti-NK tumor cells.

References 

1. Sakamoto N1,2, Ishikawa T3,4, Kokura S5,6, Okayama T7,8, Oka K9, Ideno M10, Sakai F11, Kato

A12, Tanabe M13, Enoki T14, Mineno J15, Naito Y16, Itoh Y17, Yoshikawa T18. 2. Phase I clinical trial of autologous NK cell therapy using novel expansion method in patients with

advanced digestive cancer. J Transl Med. 2015 Aug 25;13:277. doi: 10.1186/s12967-015-0632-8. 3. Pan K1, Lv L2, Zheng HX1, Zhao JJ1, Pan QZ1, Li JJ1, Weng DS1, Wang DD1, Jiang SS1, Chang

AE3, Li Q3, Xia JC1. OK-432 synergizes with IFN-γ to confer dendritic cells with enhanced antitumor

immunity. Immunol Cell Biol. 2014 Mar;92(3):263-74. doi: 10.1038/icb.2013.87. Epub 2013 Dec 3. 4. Sudo T1, Aruga A, Shimizu K, Matsushita N, Takasaki K. OK432-activated natural killer cells

enhanced trastuzumab (Herceptin)-mediated antibody-dependent cellular cytotoxicity in patients with

advanced cancer. Anticancer Res. 2006 Nov-Dec;26(6B):4327-33.

Trial dosage: A customer can apply for up to five samples a year (the actual trial dosage is determined by telephone or email communication).
Scope of use: Samples are limited to testing and research purposes.
Cost: Free for samples, customer is responsible for shipping and handling charges, reference cost is $50 in the US, €60 in the EU, and $50 in other countries.
How to apply: You can apply by telephone or by email (the email application should specify the sample name, item number, contact person, telephone number, consignee address, etc.).